Treprostinil stimulates the engraftment of haematopoetic stem cells
نویسندگان
چکیده
Background Successful transplantation of haematopoetic stem cells (HSC) is often limited by low transplantation efficiency. This may be enhanced by pharmacological means. In fact, HSCs require a Gas-transduced signal to re-populate the bone marrow [1]. Pretreatment with prostaglandin E2 (PGE2) enhances engraftment via activation of Gascoupled EP2 and EP4 receptors [2]. Treprostinil is a stable analogue of prostacyclin/PGI2. It predominantly acts via EP2 and EP4 receptors. Treprostinil is approved for treatment of pulmonary hypertension. Here we test the hypothesis that treprostinil may also be useful to promote engraftment of HSC.
منابع مشابه
Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation
Activation of Gs-coupled receptors enhances engraftment of hematopoietic stem and progenitor cells (HSPCs). We tested the hypothesis that treprostinil, a prostacyclin analog approved for the treatment of pulmonary hypertension, can be repurposed to improve hematopoietic stem cell transplantation. Murine and human HSPCs were isolated from bone marrow and umbilical cord blood, respectively. Prost...
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